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product description
Warfill is a double-coupon derivative, which combines the anticoagulant factor II, VII, ⅸ, X, thus the anticoagulant in liver intracellular is synthesized, thus extensively applied to the thrombus. Prevention and treatment of sexual diseases. Clinical practice found that there were 15.2% of hemorrhagic side effects in patients who took Warm Forest, which accounted for 3.5% of the fatal bleeding. Studies have shown that mainly because of the different pharmaceutical metabolic genes between individuals, there is a difference in drug dosage dosage of Hua legal forests, and different individuals can be more than 20 times.
Studies have found that the metabolism of Hua Fairin is mainly and CYP2C9 * 2 (C.430C> T), CYP2C9 * 3 (C.1075A> C), CYP4F2 * 3 (C.1297G> a), vkorc1 (-1639g> a) The four sites of these three genes are related. Among them, CYP2C9 * 3 is also related to the medication of the seriber, Luoshantan, etc., and CYP4F2 * 3 is also related to coumarin anticoagulant (phenxapoxin, phenxoprium soy soy). The metabolic enzyme activity of CYP2C9 * 2 and CYP2C9 * 3 mutant coding is low, which reduces the anticoagulant dosage of the corresponding patient orally. CYP4F2 * 3 (C.1297G> a) can result in reduced enzyme activity, resulting in increased vitamin K concentration, and the anticoagulant effect of Hua Faulin can reduce drug usage. Vkorc1 mutant type causes epoxidized vitamin K to reduce hydrogen-type vitamin K reduction, indirectly affect the antagonogeneous sensitivity of China's French, only a small dose can achieve anticoagulant effect, excessive, caused by hemolysis, etc. side effects.
product information
Tianlong Technology Hua Fulin Independent Pharmaceutical Solution is based on the micro-measurement technology principle of special ligase and fluorescence capture probe, which uses Tianlong micro-measurement reagent and FASCAN fluorescent quantitative analyzer to quickly obtain Chinese-related genes related genes. CYP2C9, CYP4F2 and VKORC1 site information is used to guide Chinese medicines such as Hua Farlin, Squibab, Luoshatan.
Program advantage
•Convenient operation: Sample free extraction, and reagents are pre-blended, only one step is taken, 40 minutes can be obtained.
•The hardware requirement is low: no nucleic acid extraction equipment and large sequencing equipment are required, and the general laboratory can be satisfied.
•Judging precision: powerful automatic judgment software, no subjective factors, ultimately output results in the form of a single form.
• The result is reliable: the sample has internal quality control system to ensure reliable output results.
• The reagents can be customized: testing projects can be customized to meet your personalized needs.
Clinical significance
Guide Hua Farlin, coumarin anticoagulant (glycin, phenyloxin), Sirberki cloth, Luoshatan and other individual medication, reduce poison side effects.
For people
●Coronary heart disease, thrombosis patient
●Patients with recirculating disorders after bracketing and catheter surgery
Detection gene site
Serial number | Gene | Mutation site |
1 | CYP2C9 * 2 | C.430 C> T |
2 | CYP2C9 * 3 | C.1075 a> c |
3 | CYP4F2 * 3 | C.1297 g> a |
4 | Vkorc1 | -1639 g> a |
