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product description
Statin, such as lovastatin, simvastatin, pravastatin, atorvastatin and rocathatin is the most classic and effective lipid-lowering drug, which has the effect of delaying atherosclerosis and antiportionering, and is currently widely used. Prevention and treatment of patients with cardiovascular and cerebrovascular diseases.
The study found that statins were closely related to the relaxed protein E (Apolipoprotein E, APOE), and APOE participated in blood lipids transportation, storage and excretion, affecting blood lipid levels in the body. The ApoE gene mainly has two single nucleotide polymorphisms C.388T> C and C.526C> T, which can form three haplotype E3 (388T-526C), E2 (388T-526T), E4 (388C- 526C). According to reports, ApoE4 carriers have a risk of coronary heart disease to 40% high, and the efficacy of statins is often poor or no effect, while ApoE2 carriers taking statins are the strongest.
In addition, the safety of statins also directly affects the quality of life and prognosis of patients, and affects whether the patient should take statins for a long time. Studies have shown that the key enzyme SLCO1B1 gene in statin is closely related to muscle safety. The gene encoded organic anion transport polypeptide (OATP1B1) is responsible for transferring drugs in the blood to the liver directly to act efficient or metabolism into an active substance. . C.388A> G and C.521T> C are the most common mononucleotide polymorphisms of the SLCO1B1 gene, and the mutant SLCO1B1 gene can cause the encoding OATP1B1 transporter vitality to reduce the ability to reduce the drug capacity of the liver, causing statins. Drug blood concentration increased, increasing risks of cross-stranded muscle solubiloxysis or myopathy.
product information
Tianlong Technology Statin Index Solutions are based on microose techniques for special ligase and fluorescence capture probes, using Tianlong micro-measurement reagents and FASCAN fluorescent quantitative analyzers to quickly obtain statin drug metabolism related gene ApoE The site information of SLCO1B1 is used to guide the individual medication of statins.
Program advantage
•Convenient operation: Sample free extraction, and reagents are pre-blended, only one step is taken, 40 minutes can be obtained.
•The hardware requirement is low: no nucleic acid extraction equipment and large sequencing equipment are required, and the general laboratory can be satisfied.
•Judging precision: powerful automatic judgment software, no subjective factors, ultimately output results in the form of a single form.
• The result is reliable: the sample has internal quality control system to ensure reliable output results.
• The reagents can be customized: testing projects can be customized to meet your personalized needs.
Clinical significance
Guideline the individual medication of statins, predicting the risk, efficacy and prognosis of medication.
For people
Patients with cardiovascular and cerebrovascular diseases such as hyperlipidemia, atherosclerosis
Detection gene site
Serial number | Gene | Mutation site |
1 | ApoE | C.388T> C |
2 | ApoE | C.526C> T |
3 | SLCO1B1 | C.388A> G |
4 | SLCO1B1 | C.521T> C |
